What the Bleep: Down the Rabbit Hole is a remix and second draft of the original What the #$*! Do We Know!? with some added material, most notably the Dr. Quantum cartoons (and did Ramtha smoke a pipe last time?).
The film lays a neurobiology layer atop a quantum mechanics layer in an attempt to boost the observer's quality of life. Thoughts and attitudes matter; reality is maybe more plastic than you'd presumed. In that sense, it's a religious film addressing aspects of the human condition, while piggy-backing on science's credibility to drive its message home. Like, really use those frontal lobes and make your world a better place.
I found the cosmetics too thickly applied, what with the hallmarky backgrounds, music and lighting abetting the already expressive foreground talking heads. Also, I'm philosophically biased against Abbott's Flatland meme, although I found it well-rendered, in the form of a concluding Dr. Quantum cartoon screened within the Bagdad Theater (the observer's very venue in this case).
The film doesn't have anything intelligent to say to parents in the developing world, watching their children die of medically preventable causes such as starvation. It's more aimed at relatively well cared for mid-life urbanites with little excuse to not be over themselves already.